Poroteyine yo mu bwonko bushya irashobora kuvura indwara ikomeye yo kwiheba

Ubushakashatsi buherutse gukorwa bwerekanye ko poroteyine nshyashya mu buryo bwa molekulike yo kwiheba ikorera mu ngirabuzimafatizo zo mu bwonko ishobora gukora insimburangingo yo kuvura indwara. Iyi poroteyine ifite uruhare runini mu mikurire no gukura kwingirangingo zubwonko irashobora gukorana na antidepressants mugihe cyo gukira.

Indwara ikomeye yo kwiheba isobanurwa nk '“indwara zikunda kwibasira abantu”. Ibinyabuzima byubu buryo bwo kwiheba ntibizwi. Bibaho kubera umutwaro w'amafaranga (miliyari 100 $ buri mwaka) kandi urangwa no kubaho kwubuzima bwose. Uru rupapuro ni raporo yimikorere ikora muri selile iganisha ku kwiheba. Ubushakashatsi buganisha kuri ubwo bushakashatsi bwakozwe na Ronald S Duman na bagenzi be bo muri kaminuza ya Yale kandi iki gitabo cyasohotse muri uyu mwaka mu gice cy'Urwandiko, Ukwakira k'ubuvuzi bwa Kamere.

Muri ubu bushakashatsi, urwego rwa mRNA rwakoreshejwe nkigipimo cyo kugereranya itandukaniro mubikorwa bya gene mubice bisanzwe kandi birwaye. Ingero zubwonko kubantu 21 bihebye bagize itsinda ryubushakashatsi. Icyitegererezo gisa nabantu 18 basanzwe bakusanyirijwe hamwe kugirango bapimwe. urwego rwa mRNA ya gen runaka, mkp-1, ikubye kabiri mubwonko bwabarwayi bihebye. Poroteyine MKP-1 ni igenzura ribi rya MAP Kinase caskade mu ngirabuzimafatizo. Mugihe cya dephosphorylating threonine na tirozine amino acide iyi proteyine irinda cascade ya transduction ya signal ishinzwe plastike ya neuronal, imikorere no kubaho. Itandukaniro mu mvugo ya MKP-1 ryagaragaye cyane mubintu byose byagaragaye.

Itsinda ryubushakashatsi ryashizeho kandi vivo ibimenyetso byerekana isano iri hagati ya MKP-1 no kwiheba ukoresheje imiterere yimbeba. Bagaragaje cyane MKP-1 mu bwonko bwimbeba nzima kandi bagaragaza ibimenyetso byo kwiheba. Ndetse icy'ingenzi ni ukubura depression muri izo mbeba iyo zivuwe na antidepressants. Abahanga banzuye ko MKP-1 ari intego yibintu bigabanya ubukana. Ikindi bakeka ko MKP-1 ishobora gukoreshwa nkintego yo guteza imbere imiti ivura indwara yo kwiheba.