Abashakashatsi bo muri IRB Barcelona na BSC batangaza banki nini ya videwo nini cyane ku isi
Abashakashatsi bo muri IRB Barcelona na BSC batangaza banki nini ya videwo nini cyane ku isi
Anonim

Nyuma yimyaka ine yo kubara cyane muri mudasobwa ya MareNostrum muri Centre ya Supercomputing ya Barcelona, ​​abahanga bayobowe na Modesto Orozco mu kigo cy’ubushakashatsi muri Biomedicine (IRB Barcelona) berekanye amakuru manini ku isi ashingiye kuri poroteyine. Yitwa MoDEL, iyi base base ifite proteine ​​zirenga 1, 700 kandi irashobora kugerwaho igice binyuze kuri enterineti kubashakashatsi kwisi yose. MoDEL yateguwe kugirango yige ibinyabuzima shingiro bya poroteyine no kwihutisha no koroshya imiterere yimiti mishya.

Yakomeje agira ati: “Muri iki gihe dushushanya ibiyobyabwenge nkaho poroteyine bagomba gukora zihagaze kandi ibi bigana inzira ndende yo gusobanura ibitagenze neza mu guteza imbere imiti mishya kuko ibi atari ibintu byukuri. Hamwe na MoDEL iki kibazo cyakemutse kuko gitanga uyikoresha kuva kumafoto 10 000 000 kugeza 100.000 kuri poroteyine, kandi ibyo biganisha kuri izi nyubako kandi bikemerera igishushanyo mbonera ", ibi bikaba byavuzwe na Orozco, umuyobozi wa" Molecular modeling na bioinformatics ". itsinda muri IRB Barcelona, ​​umuyobozi wa gahunda yubuzima bwikigo cya Barcelona Supercomputing Centre hamwe numwarimu wuzuye muri kaminuza ya Barcelona. Nk’uko uyu mushakashatsi abitangaza ngo amasosiyete menshi y’imiti asanzwe akoresha ingamba za MoDEL mu gutegura imiti ya mbere irwanya kanseri n’indwara ziterwa n’umuriro, zishobora kuboneka muri uyu mwaka.

Umushinga wo kwaguka

Abashakashatsi batezimbere MoDEL bakora kuva kurutonde mpuzamahanga rwububiko bwa poroteyine (hafi 40 000) bita Protein Data Bank (PDB). "Video 1, 700 za poroteyine zo muri 40 000 000 zigize PDB zishobora kugaragara nkigice gito, ariko inyubako nyinshi muri PDB zirasa cyane. Kubwibyo, dukurikije amahame yashyizweho ku rwego mpuzamahanga, duhagarariye hafi 40% bya poroteyine zifite imiterere izwi”.

Ariko kuri Modesto Orozco ingingo yingenzi cyane nuko MoDEL ubu irimo gukwirakwiza ibice birenga 30% byubaka poroteyine zabantu bifitemo inyungu za farumasi, ni ukuvuga ko zishobora kwibasirwa nibiyobyabwenge. Yakomeje agira ati: "Twabonye iyi datum binyuze mu kizamini gikomeye cyane ku buryo twibwira ko mu byukuri dukubiyemo byinshi. Ariko, MoDEL izakomeza gutera imbere kandi ibyo birashobora kugerwaho byihuse kuko sisitemu yashyizweho neza”. Abashakashatsi bavuga ko intego nyamukuru ari ukwibanda kuri poroteyine zifite akamaro mu ndwara z’abantu kandi mu gihe kiri hagati y’imyaka 2 na 3 zikubiyemo 80% by’imiti.

Mu rwego rwo gukora umushinga wa MoDEL, Orozco nitsinda rye bashyigikiwe nubutunzi butangwa na IRB Barcelona, ​​Centre ya Barcelona SuperComputing, Fondasiyo ya Marcelino Botín, Fundación Genoma España, Ikigo cyigihugu cya Bioinformatics ndetse n’imishinga myinshi y’uburayi.

Bikunzwe cyane