Inkingo za Kanseri yintanga zirashobora gukorwa vuba vuba
Inkingo za Kanseri yintanga zirashobora gukorwa vuba vuba
Anonim

Abashakashatsi bavuga ko bashobora kugabanya igihe cyo gukora urukingo rwa dendritic ku barwayi bafite kanseri igaruka kenshi muri ovaries, peritoneum primaire, cyangwa tebes.

Inyungu zigihe gito zirimo kuzigama amafaranga, nkuko ubushakashatsi bwakozwe nabashakashatsi bo muri kaminuza ya Pennsylvania bwasohotse mu nomero yUkuboza ya PLoS ONE.

Ati: "Akazi kacu karerekana ko utugingo ngengabuzima twa dendritic dushobora gukorwa hamwe nigiciro cyiza kandi tugakomeza imbaraga zazo nyuma yo kwishyiriraho ibibyimba byabarwayi. Ubu ni uburyo bwihariye bwo gukingira indwara, bushobora gutegurwa ku buryo bworoshye ku barwayi benshi barwaye kanseri y'intanga barimo kubagwa kugira ngo bakureho ibibyimba byabo.”Umwanditsi mukuru George Coukos.

Coukos ni umuyobozi w'ikigo gishinzwe ubushakashatsi kuri kanseri ya Ovarian muri Centre ya Kanseri ya Abramson ya kaminuza ya Pennsylvania.

Abahanga mbere bahanuye ko inkingo zishobora gutera umurwayi indwara y’umubiri kwibasira ibibyimba no kurwanya indwara. Ingirabuzimafatizo ya Dendritic ni inzira itanga icyizere cyo kuvura indwara, cyane cyane ku barwayi bafite ibibyimba bito cyangwa abarwayi bakira.

Abanditsi b'ubushakashatsi bavuze ko utugingo ngengabuzima twa dendritic turimo antigen yibibyimba iyo ikozwe neza ishobora gukora sisitemu yumubiri kugirango yibasire kanseri kandi ikabuza ikibyimba.

Ubushakashatsi bwakozwe bwerekanye ko inkingo za dendritic selile zirimo poroteyine imwe ya poroteyine zashoboraga kugabanya kanseri y'ibere mbere yo gutera mu minsi ibiri gusa, kandi byatekerezwaga ko izo antigene zisaba iminsi irindwi yo gukura mbere yuko zikoreshwa.

Ariko, Coukos hamwe nitsinda rye bemeje ko utugingo ngengabuzima twa dendritic dushobora gukura mumico muminsi ine gusa kandi bikora neza nkuko selile zikura muminsi irindwi.

Itsinda ry’ubushakashatsi ryatandukanije monocytes yamaraso ya periferique, ubwoko bwamaraso yera, kubushake bwubuzima n’abarwayi ba kanseri y’intanga, kandi bakoresheje protocole yo mu rwego rw’amavuriro, iryo tsinda ryashishikarije ingirabuzimafatizo kwitandukanya na selile dendritic idakuze ihura na lysate yose yibibyimba bibiri., iminsi ine cyangwa irindwi.

Iyo abashakashatsi bagereranije ibimenyetso bya poroteyine hejuru yutugingo ngengabuzima, kuruta gusanga nubwo ubwinshi bwingirabuzimafatizo ya dendritic butarakura muminsi ibiri, ubwinshi bwingirabuzimafatizo zikuze kumunsi wa kane.

Abashakashatsi basanze ingirabuzimafatizo ya dendritic umunsi-ine yatumye T-selile itangwa n’abarwayi ba kanseri ndetse n’abaterankunga bazima mu bushakashatsi bwakozwe na test tube, kandi ko ibyo bisubizo byagereranywa na selile-dendritic selile.

"Dufatiye ku mikorere isumba iyindi yose yateguwe na lysate yateguwe na antigene zasobanuwe na molekile zinkingo za kanseri hamwe n’ubusumbane rusange bw’inkingo zishingiye kuri selile dendritic, ibisubizo byacu bitanga amakuru y’ibanze kugira ngo iterambere ryihuse ry’inkingo zikomeye, zifite ubudahangarwa bukabije bwo kuvura ibibyimba byinshi bwoko, "ibi bikaba byavuzwe n'umwanditsi Cheryl Lai-Lai Chiang, umushakashatsi nyuma ya dogiteri muri iki kigo.

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